研究

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私たちの研究活動

私たちは地域に根ざすアカデミアとして,医科学の追究とともに地域の診療水準と疾病対策の向上に貢献するエビデンスを国内外に積極的に発信することを社会的な使命と考えています。そのために本学が中心となって運営する質の高い地域コホート研究はもちろん,厚労省やAMEDなどの全国レベルの公的班研究,国際共同研究に積極的に参画し,学内外の研究者とチームを組んで研究活動を展開しています。
リアルワールドの丁寧な観察と日常の診療実践の検証を重視し、臨床的な仮説に立脚した探索的・基礎的研究へ展開してゆくことを目指しています。


主な研究資源

地域住民コホート

  1. 岩手県北地域コホート研究(Iwate KENCO study)
  2. 岩手県における東日本大震災被災者の支援を目的とした大規模コホート研究(RIAS)
  3. いわて東北メディカルメガバンク事業

全国規模健診受診者コホート

  1. 特定健診研究(The Japan Specific Health Checkups Study: J-SHC study)(厚労科研,AMED)

国際共同研究

  1. Chronic Kidney Disease Prognosis Consortium:CKD-PC(KDIGO)
  2. The Chronic Kidney Disease Outcomes and Practice Patterns Study : CKDopps(Arbor Research Collaborative for Health)


主な研究テーマ

  • 大規模コホートを用いた生活習慣病/慢性腎臓病/心血管病の発症進展の要因解析 上記1-4)
  • 慢性腎臓病の疫学の国際比較 上記4,5)
  • 腎臓病診療プラクティスと患者立脚型アウトカムの検証と国際比較 上記6)ほか
  • ゲノムワイド関連解析(GWAS)に基づく腎疾患リスクならびに治療標的の同定 上記3)
  • 腎不全における生体内レドックス制御の分子機序と治療
  • 腎不全における全身多臓器連関の病態と治療
  • 腎疾患重症化予防のための多因子治療の開発ならびに地域保健医療連携 など


研究成果
(英文論文のみ 2018年4月以降)

2021年

  • Nishimoto M, Murashima M, Yoshida H, Eriguchi M, Tasaki H, Fukata F, Kosugi T, Matsui M, Samejima KI, Iseki K, Asahi K, Yamagata K, Fujimoto S, Konta T, Narita I, Moriyama T, Kasahara M, Shibagaki Y, Kondo M, Watanabe T, Tsuruya K; Japan Specific Health Checkups (J-SHC) Study Group. Impact of self-reported walking habit on slower decline in renal function among the general population in a longitudinal study: the Japan Specific Health Checkups (J-SHC) Study. J Nephrol. 2021 Apr 30. Online ahead of print.
  • Otaki Y, Konta T, Ichikawa K, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T. Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study. Sci Rep. 2021; 11: 8999.
  • Hoshino J, Tsunoda R, Nagai K, Kai H, Saito C, Ito Y, Asahi K, Kondo M, Iseki K, Iseki C, Okada H, Kashihara N, Narita I, Wada T, Combe C, Pisoni RL, Robinson BM, Yamagata. Comparison of annual eGFR decline among primary kidney diseases in patients with CKD G3b-5: results from a REACH-J CKD cohort study. Clin Exp Nephrol. 2021 Apr 21. Online ahead of print.
  • K.Nagai K, Asahi K, Iseki K, Yamagata K. Estimating the prevalence of definitive chronic kidney disease in the Japanese general population. Clin Exp Nephrol. 2021 Apr 10. Online ahead of print.
  • Otaki Y, Watanabe T, Konta T, Watanabe M, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Impact of chronic kidney disease on aortic disease-related mortality: a four-year community-based cohort study. Intern Med. 2021; 60: 689-697.
  • Wakasugi M, Narita I, Iseki K, Asahi K, Yamagata K, Fujimoto S, Moriyama T, Konta T, Tsuruya K, Kasahara M, Shibagaki Y, Kondo M, Watanabe T. The effect of CKD on associations between lifestyle factors and all-cause, cancer, and cardiovascular mortality: a population-based cohort study. Intern Med. 2021 Feb 15. Online ahead of print.
  • Saito H, Tanaka K, Iwasaki T, Oda A, Watanabe S, Kanno M, Kimura H, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease. Sci Rep. 2021; 11: 1380.
  • Iwasaki M, Kudo A, Asahi K, Machii N, Iseki K, Satoh H, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M. Fast walking is a preventive factor against new-onset diabetes mellitus in a large cohort from a Japanese general population. Sci Rep. 2021; 11: 716.
  • Tanaka K, Saito H, Iwasaki T, Oda A, Watanabe S, Kanno M, Kimura H, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Association between serum potassium levels and adverse outcomes in chronic kidney disease: the Fukushima CKD cohort study. Clin Exp Nephrol. 2021 Jan 7.

2020年

  • Matsuura Y, Tanaka F, Segawa T, Tanno K, Sakata K, Ohsawa M, Omama S, Ogasawara K, Asahi K, Nakamura M. Sex differences in the influence of elevated serum uric acid levels for cardiovascular risk in the general population with normal renal function. J Iwate Med Assoc. 2020; 72:145-155.
  • Iseki K, Konta T, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Watanabe T. Higher cardiovascular mortality in men with persistent dipstick hematuria. Clin Exp Nephrol. 2020 Sep 22.
  • Osaki T, Satoh M, Tanaka F, Tanno K, Takahashi Y, Nasu T, Sakata K, Morino Y, Sobue K, Sasaki M: The Value of a Cystatin C-based Estimated Glomerular Filtration Rate for Cardiovascular Assessment in a General Japanese Population: Results From the Iwate Tohoku Medical Megabank Project. J Epidemiol. 2020; 30: 260-267.
  • Hoshino J, Muenz D, Zee J, Sukul N, Speyer E, Guedes M, Lopes AA, Asahi K, van Haalen H, James G, Dhalwani N, Pecoits-Filho R, Bieber B, Robinson BM, Pisoni RL; CKDopps Investigators. Associations of Hemoglobin Levels With Health- Related Quality of Life, Physical Activity, and Clinical Outcomes in Persons With Stage 3-5 Nondialysis CKD. J Ren Nutr. 2020; 30: 404-414.
  • Otaki Y, Watanabe T, Konta T, Watanabe M, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Impact of hyperuricemia on mortality related to aortic diseases: a 3.8-year nationwide community-based cohort study. Sci Rep. 2020; 10: 14281.
  • Otaki Y, Watanabe T, Konta T, Watanabe M, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Impact of calculated plasma volume status on all-cause and cardiovascular mortality: 4-year nationwide community-based prospective cohort study. PLoS One. 2020; 15: e0237601.
  • Hatano Y, Yano Y, Fujimoto S, Sato Y, Iseki K, Konta T, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T. The population-attributable fraction for premature mortality due to cardiovascular disease associated with stage 1 and 2 hypertension among Japanese. Am J Hypertens. 2020 Aug 5: hpaa128.
  • Sato Y, Fujimoto S, Iseki K, Konta T, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T. Higher baseline uric acid concentration is associated with non-attainment of optimal blood pressure. PLoS One. 2020; 15: e0236602.
  • Iseki K, Konta T, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Iseki C, Watanabe T. Impact of Metabolic Syndrome on the Mortality Rate among Participants in a Specific Health Check and Guidance Program in Japan. Intern Med. 2020; 59: 2671-2678.
  • Tanabe H, Saito H, Kudo A, Machii N, Hirai H, Maimaituxun G, Tanaka K, Masuzaki H, Watanabe T, Asahi K, Kazama J, Shimabukuro M. Factors Associated with Risk of Diabetic Complications in Novel Cluster-Based Diabetes Subgroups: A Japanese Retrospective Cohort Study. J Clin Med. 2020; 9: 2083.
  • Tanabe H, Saito H, Machii N, Kudo A, Tanaka K, Asahi K, Kazama JJ, Shimabukuro M. Burden of Undiagnosed Type 2 Diabetes in Diabetic Kidney Disease: A Japanese Retrospective Cohort Study. J Clin Med. 2020; 9: 2028.
  • Tanaka F, Komi R, Nakamura M, Tanno K, Onoda T, Ohsawa M, Sakata K, Omama S, Ogasawara K, Ishibashi Y, Yonekura Y, Itai K, Kuribayashi T, Kikuchi Y, Ishigaki Y, Okayama A, Asahi K; Iwate-Kenco Study Group. Additional prognostic value of electrocardiographic left ventricular hypertrophy in traditional cardiovascular risk assessments in chronic kidney disease. J Hypertens. 2020; 38: 1149-1157.
  • Ikeda T, Inoue S, Konta T, Murakami M, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T. Can Daily Walking Alone Reduce Pneumonia-Related Mortality among Older People? Sci Rep. 2020; 10: 8556.
  • Nakajima A, Tanaka K, Saito H, Iwasaki T, Oda A, Kanno M, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Blood pressure control in chronic kidney disease according to underlying renal disease: the Fukushima CKD cohort. Clin Exp Nephrol. 2020; 24: 427-434.
  • Konta T, Ichikawa K, Kawasaki R, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T. Association between serum uric acid levels and mortality: a nationwide community-based cohort study. Sci Rep. 2020; 10: 6066.

2019年

  • Nagai K, Yamagata K, Iseki K, Moriyama T, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T. Antihypertensive treatment and risk of cardiovascular mortality in patients with chronic kidney disease diagnosed based on the presence of proteinuria and renal function: A large longitudinal study in Japan. PLoS One. 2019; 14: e0225812.
  • Nagai K, Yamagata K, Iseki K, Moriyama T, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T: Cause-specific mortality in the general population with transient dipstick-proteinuria. PLoS One. 2019; 14: e0223005.
  • Nishimoto M, Tagawa M, Matsui M, Eriguchi M, Samejima KI, Iseki K, Iseki C, Asahi K, Yamagata K, Konta T, Fujimoto S, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Watanabe T, Tsuruya K: A prediction model with lifestyle in addition to previously known risk factors improves its predictive ability for cardiovascular death. Sci Rep. 2019; 9: 12953.
  • Takahashi Y, Satoh M, Ohmomo H, Tanaka F, Osaki T, Tanno K, Nasu T, Sakata K, Morino Y, Sobue K, Sasaki M: Association between high-sensitivity cardiac troponin T and future cardiovascular incidence in a general Japanese population: results from the Tohoku medical megabank project. Biomarkers. 2019; 24: 566-573.
  • Uchida D, Kido R, Kawarazaki H, Murasawa M, Ando A, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Konta T, Narita I, Kondo M, Kasahara M, Asahi K, Watanabe T, Shibagaki Y: Lower diastolic blood pressure was associated with higher incidence of chronic kidney disease in the general population only in those using antihypertensive medications. Kidney Blood Press Res. 2019; 44: 973-983.
  • Nagai K, Iseki C, Iseki K, Kondo M, Asahi K, Saito C, Tsunoda R, Okubo R, Yamagata K: Higher medical costs for CKD patients with a rapid decline in eGFR: a cohort study from the Japanese general population. PLoS One. 2019; 14: e0216432.
  • Sukul N, Speyer E, Tu C, Bieber BA, Li Y, Lopes AA, Asahi K, Mariani L, Laville M, Rayner HC, Stengel B, Robinson BM, Pisoni RL; CKDopps and CKD-REIN investigators: Pruritus and patient reported outcomes in non-dialysis CKD. Clin J Am Soc Nephrol. 2019; 14: 673-681.
  • Sakamoto M, Edo N, Takahashi S, Okamura E, Uno K, Morita K, Ishikawa T, Asahi K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kimura K, Ohashi Y, Watanabe T, Tsukamoto K: Association between prescription and control status of dyslipidemia and hypertension among Japanese patients with diabetes. J Atheroscler Thromb. 2019; 26: 805-820.
  • Hirai H, Asahi K, Yamaguchi S, Mori H, Satoh H, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M. New risk prediction model of coronary heart disease in participants with and without diabetes: Assessments of the Framingham risk and Suita scores in 3-year longitudinal database in a Japanese population. Sci Rep. 2019; 9: 2813.
  • Okada H, Yasuda Y, Kashihara N, Asahi K, Tanaka K, et al. Essential points from Evidence-based Clinical Practice Guidelines for Chronic Kidney Disease 2018. Clin Exp Nephrol. 2019; 23: 1-15.

2018年

  • Otaki Y, Watanabe T, Konta T, Watanabe M, Fujimoto S, Sato Y, Asahi K, Yamagata K, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Effect of Hypertension on Aortic Artery Disease-Related Mortality - 3.8-Year Nationwide Community-Based Prospective Cohort Study. Circ J. 2018; 82: 2776-2782.
  • Ogata E, Asahi K, Yamaguchi S, Iseki K, Sato H, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M. Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population. Sci Rep. 2018 Sep 17; 8:13927.
  • Tanaka K, Tanaka F, Onoda T, Tanno K, Ohsawa M, Sakata K, Omama S, Ogasawara K, Ishibashi Y, Itai K, Kuribayashi T, Okayama A, Nakamura M; Iwate-Kenco Study Group. Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population. Am J Hypertens. 2018; 31: 895-901.
  • Komi R, Tanaka F, Omama S, Ishibashi Y, Tanno K, Onoda T, Ohsawa M, Tanaka K, Okayama A, Nakamura M; Iwate-Kenco Study Group. Burden of high blood pressure as a contributing factor to stroke in the Japanese community-based diabetic population. Hypertens Res. 2018; 41: 531-538.


受賞

  • 2022年6月に神戸市で開催されました第65回日本腎臓学会学術総会にて、松浦佑樹医師が優秀論文賞を受賞いたしました。
    受賞論文:First case report of monoclonal IgG3-heavy-chain glomerulonephritis with microtubular structures【CEN Case Reports(2021)10:236-240】

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