研究

主な研究資源

地域住民コホート

1. 岩手県北地域コホート研究
2. 岩手県における東日本大震災被災者の支援を目的とした大規模コホート研究
3. いわて東北メディカルメガバンク事業

国内共同研究

1. 特定健診研究（The Japan Specific Health Checkups Study: J-SHC study）（全国規模健診受診者コホート)
2. 福島CKDコホート

国際共同研究

1. Chronic Kidney Disease Prognosis Consortium：CKD-PC（KDIGO)
2. The Chronic Kidney Disease Outcomes and Practice Patterns Study : CKDopps（Arbor Research Collaborative for Health）

研究成果
（英文論文のみ　2018年4月以降）

2025年

• 1. Asahi K, Konta T, Tamura K, Tanaka F, Fukui A, Nakamura Y, Hirose J, Ohara K, Shijoh Y, Carter M, Meredith K, Harris J, Åkerborg Ö, Kashihara N, Yokoo T. The health-economic impact of urine albumin-to-creatinine ratio testing for chronic kidney disease in Japanese patients with type 2 diabetes. J Diabetes Investig. 2025;16:108-119.
  2. Kosugi T, Eriguchi M, Yoshida H, Tamaki H, Uemura T, Tasaki H, Furuyama R, Nishimoto M, Matsui M, Samejima KI, Iseki K, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kasahara M, Shibagaki Y, Kondo M, Asahi K, Watanabe T, Tsuruya K. Association of body indices with mortality in older population: Japan Specific Health Checkups (J-SHC) Study. J Am Geriatr Soc. 2025; 73: 150-161.
  3. Fujiwara M, Kimura H, Tanaka K, Saito H, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Association between malnutrition and adverse renal outcomes in patients with type 2 diabetes. J Diabetes Investig. 2025; 16: 100-107.

2024年

• 1. Otaki Y, Watanabe T, Konta T, Watanabe M, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Macrocytic anemia, kidney dysfunction, and mortality in general population: Japan specific health checkup study. Sci Rep. 2024; 14: 32005.
  2. Konta T, Asahi K, Tamura K, Tanaka F, Fukui A, Nakamura Y, Hirose J, Ohara K, Shijoh Y, Carter M, Meredith K, Harris J, Åkerborg Ö, Kashihara N, Yokoo T. The health-economic impact of urine albumin-to-creatinine ratio testing for chronic kidney disease in Japanese non-diabetic patients. Clin Exp Nephrol. 2024 Dec 16. (Epub ahead of print)
  3. Ejiri H, Tanaka K, Kimura H, Saito H, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Predictive values of four nutritional indices for adverse outcomes in patients with hypertension. Clin Exp Nephrol. 2024 Nov 5. (Epub ahead of print).
  4. Kosugi T, Eriguchi M, Yoshida H, Tamaki H, Uemura T, Tasaki H, Furuyama R, Fukata F, Nishimoto M, Matsui M, Samejima KI, Iseki K, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kasahara M, Shibagaki Y, Kondo M, Asahi K, Watanabe T, Tsuruya K. Serum High-Density Lipoprotein Cholesterol Levels and the Risk of Kidney Function Decline: The Japan Specific Health Checkups (J‑SHC) Study. J Atheroscler Thromb. 2024 Sep 21. (Epub ahead ofPrint)
  5. Nihei S, Asaka J, Yaegashi M, Asahi K, Kudo K. Effect of blood pressure control on the risk of proteinuria during bevacizumab treatment in patients with colorectal cancer: a single-center retrospective cohort study. J Pharm Health Care Sci. 2024; 10: 51.
  6. Tanaka K, Kimura H, Ejiri H, Saito H, Watanabe K, Kazama S, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Geriatric Nutritional Risk Index is associated with adverse outcomes in patients with hypertension: the Fukushima Cohort study. Hypertens Res. 2024; 47: 2041-2052.
  7. Matsumoto A, Nagasawa Y, Yamamoto R, Shinzawa M, Yamazaki H, Shojima K, Shinmura K, Isaka Y, Iseki K, Yamagata K, Narita I, Konta T, Kondo M, Tsuruya K, Kasahara M, Shibagaki Y, Fujimoto S, Asahi K, Watanabe T, Moriyama T. Cigarette smoking and progression of kidney dysfunction: a longitudinal cohort study. Clin Exp Nephrol. 2024; 28: 793-802.
  8. Saito H, Tanaka K, Ejiri H, Kimura H, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Elevated resting heart rate is associated with mortality in patients with chronic kidney disease. Sci Rep. 2024; 14: 17372.
  9. Tamaki H, Eriguchi M, Yoshida H, Uemura T, Tasaki H, Nishimoto M, Kosugi T, Samejima KI, Iseki K, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kasahara M, Shibagaki Y, Kondo M, Asahi K, Watanabe T, Tsuruya K. Pulse pressure modifies the association between diastolic blood pressure and decrease in kidney function: the Japan Specific Health Checkups Study. Clin Kidney J. 2024 ;17: sfae152.
  10. Saito H, Yoshimura H, Tanaka K, Kimura H, Watanabe K, Tsubokura M, Ejiri H, Zhao T, Ozaki A, Kazama S, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Predicting CKD progression using time-series clustering and light gradient boosting machines. Sci Rep. 2024; 14: 1723
  11. Takahashi N, Tsubota-Utsugi M, Takahashi S, Yonekura Y, Ohsawa M, Kuribayashi T, Onoda T, Takanashi N, Sakata K, Yamada T, Ogasawara K, Omama S, Tanaka F, Asahi K, Ishigaki Y, Itabashi R, Itamochi H, Takahashi F, Okayama A, Tanno K. Sex- and age-specific associations between metabolic syndrome and future functional disability in the Japanese older population. Inquiry. 2024; 61: 469580241273103.

2023年

• 1. Numazaki H, Nasu T, Satoh M, Kotozaki Y, Tanno K, Asahi K, Ohmomo H, Shimizu A, Omama S, Morino Y, Sobue K, Sasaki M. Association between vascular endothelial dysfunction and stroke incidence in the general Japanese population: Results from the tohoku medical megabank community-based cohort study. Int J Cardiol Cardiovasc Risk Prev. 2023; 19: 200216.
  2. Tasaki H, Eriguchi M, Yoshida H, Uemura T, Fukata F, Nishimoto M, Kosugi T, Matsui M, Samejima KI, Iseki K, Asahi K, Yamagata K, Konta T, Fujimoto S, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Watanabe T, Tsuruya K. Synergistic effect of proteinuria on dipstick hematuria-related decline in kidney function: The Japan Specific Health Checkups (J-SHC) Study. Clin Exp Nephrol. 2023; 27: 990-1000.
  3. Tsubota-Utsugi M, Tanno K, Takahashi N, Onoda T, Yonekura Y, Ohsawa M, Takahashi S, Kuribayashi T, Itabashi R, Tanaka F, Asahi K, Omama S, Ogasawara K, Ishigaki Y, Takahashi F, Soma A, Takanashi N, Sakata K, Ohkubo T, Okayama A. Rapid weight change as a predictor of disability among community-dwelling Japanese older adults. Geriatr Gerontol Int. 2023; 23: 809-816.
  4. Kosugi T, Eriguchi M, Yoshida H, Tamaki H, Uemura T, Tasaki H, Furuyama R, Fukata F, Nishimoto M, Matsui M, Samejima KI, Iseki K, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kasahara M, Shibagaki Y, Kondo M, Asahi K, Watanabe T, Tsuruya K. Trace proteinuria detected via dipstick test is associated with kidney function decline and new-onset overt proteinuria: the Japan Specific Health Checkups (J-SHC) Study. Clin Exp Nephrol. 2023; 27: 801-808.
  5. Kimura H, Tanaka K, Saito H, Iwasaki T, Kazama S, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Impact of red blood cell distribution width-albumin ratio on prognosis of patients with CKD. Sci Rep. 2023; 13: 15774.
  6. Harada T, Nagai K, Mase K, Tsunoda R, Iseki K, Moriyama T, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T, Yamagata K. Elevated Crude Mortality in Obese Chronic Kidney Disease Patients with Loss of Exercise Habit: A Cohort Study of the Japanese General Population. Intern Med. 2023; 62: 2171-2179.
  7. Nagai K, Harada T, Mase K, Iseki K, Moriyama T, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T, Yamagata K. Weight Loss Improves Liver Dysfunction and Dipstick Proteinuria in Obesity: The Japan Specific Health Checkups Study. JMA J. 2023; 6: 312-320.
  8. Otaki Y, Watanabe T, Konta T, Watanabe M, Fujimoto S, Sato Y, Asahi K, Yamagata K, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population. J Atheroscler Thromb. 2023; 30: 754-766.
  9. Murano H, Inoue S, Sato K, Sato M, Igarashi A, Fujimoto S, Iseki K, Moriyama T, Shibagaki Y, Kasahara M, Narita I, Yamagata K, Tsuruya K, Kondo M, Asahi K, Watanabe T, Konta T, Watanabe M. The effect of lifestyle on the mortality associated with respiratory diseases in the general population. Sci Rep. 2023 ; 13: 8272.
  10. Nihei S, Ikeda T, Aoki T, Murasato F, Yaegashi M, Asahi K, Kudo K. Plasma endothelin-1 may predict bevacizumab-induced proteinuria in patients with colorectal cancer. Cancer Chemother Pharmacol. 2023; 91: 427-434.
  11. Mikami T, Tanno K, Sasaki R, Takanashi N, Kotozaki Y, Asahi K, Tanaka F, Omama S, Kogure M, Nakaya N, Nakamura T, Tsuchiya N, Narita A, Hozawa A, Hitomi J, Sakata K, Sasaki M. Association between the extent of house collapse and urine sodium-to-potassium ratio of victims affected by the 2011 Great East Japan Earthquake and Tsunami: a cross-sectional study. Hypertens Res. 2023; 46:1247-1256.
  12. Kosugi T, Eriguchi M, Yoshida H, Uemura T, Tasaki H, Fukata F, Nishimoto M, Matsui M, Samejima KI, Iseki K, Fujimoto S, Konta T, Moriyama T, Yamagata K, Ichiei N, Kasahara M, Shibagaki Y, Kondo M, Asahi K, Watanabe T, Tsuruya K. Height loss is associated with decreased kidney function: The Japan Specific Health Checkups (J-SHC) Study. Geriatr Gerontol Int. 2023; 23: 282-288.
  13. Kimura Y, Yamamoto R, Shinzawa M, Aoki K, Tomi R, Ozaki S, Yoshimura R, Shimomura A, Iwatani H, Isaka Y, Iseki K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T, Yamagata K, Moriyama T. Alcohol consumption and a decline in glomerular filtration rate: The Japan Specific Health Checkups Study. Nutrients. 2023; 15: 1540.
  14. Iwasaki T, Kimura H, Tanaka K, Asahi K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Watanabe T, Kazama JJ. Association between height loss and mortality in the general population. Sci Rep. 2023; 13: 3593
  15. Kimura H, Tanaka K, Saito H, Iwasaki T, Watanabe S, Kazama S, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Association of polypharmacy with incidence of CKD: a retrospective cohort study. Clin Exp Nephrol. 2023; 27:272-278.
  16. Saito H, Tanaka K, Iwasaki T, Oda A, Watanabe S, Kobari E, Kimura H, Kazama S, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Hematological parameters of anemia and prognosis of non-dialysis-dependent chronic kidney disease: the Fukushima CKD cohort study. Clin Exp Nephrol. 2023; 27: 55-65.
  17. Kobayashi T, Nasu T, Satoh M, Kotozaki Y, Tanno K, Asahi K, Ohmomo H, Shimizu A, Omama S, Kikuchi H, Taguchi S, Morino Y, Sobue K, Sasaki M. Association between high-sensitivity cardiac troponin T levels and incident stroke in the elderly Japanese population: Results from the Tohoku Medical Megabank Community-based Cohort Study. Am Heart J Plus. 2022; 22: 100212

2022年

• 1. Taguchi S, Nasu T, Satoh M, Kotozaki Y, Tanno K, Tanaka F, Asahi K, Ohmomo H, Kikuchi H, Kobayashi T, Morino Y, Shimizu A, Sobue K, Sasaki M. Association between plasma xanthine oxidoreductase activity and the renal function in a general Japanese population: the Tohoku Medical Megabank community-based cohort study. Kidney Blood Press Res. 2022; 47: 722-728.
  2. Kikuchi Y, Odashima Y, Yoshikawa K, Oda T, Tanaka F, Oikawa H, Ishigaki Y, Asahi K. Renal thrombotic microangiopathy and nephrotic proteinuria induced by intravitreal injection of aflibercept for diabetic macular edema. BMC Nephrol. 2022; 23: 348.
  3. Kimura H, Asahi K, Tanaka K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Watanabe T, Kazama JJ. Health-related behavioral changes and incidence of chronic kidney disease: the Japan Specific Health Checkups (J-SHC) study. Sci Rep. 2022; 12: 16319.
  4. Kawano K, Otaki Y, Suzuki N, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T, Konta T. Prediction of mortality risk of health checkup participants using machine learning-based models: the J-SHC study. Sci Rep. 2022; 12: 14154.
  5. Kikuchi H, Nasu T, Satoh M, Kotozaki Y, Tanno K, Asahi K, Ohmomo H, Kobayashi T, Taguchi S, Morino Y, Shimizu A, Sobue K, Sasaki M. Association between total type I collagen N-terminal propeptide and coronary artery disease risk score in the general Japanese population. Int J Cardiol Heart Vasc. 2022; 41: 101056.
  6. Wakasugi M, Narita I, Iseki K, Asahi K, Yamagata K, Fujimoto S, Moriyama T, Konta T, Tsuruya K, Kasahara M, Shibagaki Y, Kondo M, Watanabe T; Japan Specific Health Checkups (J-SHC) Study Group. Healthy lifestyle and incident hypertension and diabetes in participants with and without chronic kidney disease: the Japan Specific Health Checkups (J-SHC) study. Intern Med. 2022; 61: 2841-2851.
  7. Okubo R, Hoshi SL, Kimura T, Kondo M, Asahi K, Iseki C, Fujimoto S, Narita I, Nishiyama H, Yamagata K, Iseki K. Cost-effectiveness of mass screening for dipstick hematuria in Japan. Clin Exp Nephrol. 2022; 26: 398-412.
  8. Oda A, Tanaka K, Saito H, Iwasaki T, Watanabe S, Kimura H, Kazama S, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Association between serum inorganic phosphorus levels and adverse outcomes in chronic kidney disease: the Fukushima CKD cohort study. Intern Med. 2022; 61: 1653-1662.
  9. Hibino M, Otaki Y, Kobeissi E, Pan H, Hibino H, Taddese H, Majeed A, Verma S, Konta T, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Asahi K, Watanabe T, Watanabe T, Watanabe M, Aune D. Blood pressure, hypertension, and the risk of aortic dissection incidence and mortality: results from the J-SHC study, the UK Biobank study, and a meta-analysis of cohort studies. Circulation. 2022; 145: 633-644.

2021年

• 1. Ogishima S, Nagaie S, Mizuno S, Ishiwata R, Iida K, Shimokawa K, Takai-Igarashi T, Nakamura N, Nagase S, Nakamura T, Tsuchiya N, Nakaya N, Murakami K, Ueno F, Onuma T, Ishikuro M, Obara T, Mugikura S, Tomita H, Uruno A, Kobayashi T, Tsuboi A, Tadaka S, Katsuoka F, Narita A, Sakurai M, Makino S, Tamiya G, Aoki Y, Shimizu R, Motoike IN, Koshiba S, Minegishi N, Kumada K, Nobukuni T, Suzuki K, Danjoh I, Nagami F, Tanno K, Ohmomo H, Asahi K, Shimizu A, Hozawa A, Kuriyama S; Tohoku Medical Megabank Project Study Group; Fuse N, Tominaga T, Kure S, Yaegashi N, Kinoshita K, Sasaki M, Tanaka H, Yamamoto M. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Hum Genome Var. 2021; 8: 44.
  2. Tanno K, Yonekura Y, Okuda N, Kuribayashi T, Yabe E, Tsubota-Utsugi M, Omama S, Onoda T, Ohsawa M, Ogasawara K, Tanaka F, Asahi K, Itabashi R, Ito S, Ishigaki Y, Takahashi F, Koshiyama M, Sasaki R, Fujimaki D, Takanashi N, Takusari E, Sakata K, Okayama A. Association between milk intake and incident stroke among Japanese community dwellers: the Iwate-KENCO study. Nutrients. 2021; 13: 3781.
  3. Kimura H, Tanaka K, Saito H, Iwasaki T, Oda A, Watanabe S, Kanno M, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Association of polypharmacy with kidney disease progression in adults with CKD. Clin J Am Soc Nephrol. 2021; 16: 1797-1804.
  4. Otaki Y, Watanabe T, Konta T, Watanabe M, Fujimoto S, Sato Y, Asahi K, Yamagata K, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. One-year change in diastolic blood pressure and aortic disease-related mortality in a Japanese general population aged 50-75 years. Circ J. 2021; 85: 2222-2231.
  5. Matsui M, Tsuruya K, Yoshida H, Iseki K, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kasahara M, Shibagaki Y, Kondo M, Asahi K, Watanabe T. Trace proteinuria as a risk factor for cancer death in a general population. Sci Rep. 2021; 11: 16890.
  6. Kosugi T, Eriguchi M, Yoshida H, Tasaki H, Fukata F, Nishimoto M, Matsui M, Samejima KI, Iseki K, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kasahara M, Shibagaki Y, Kondo M, Asahi K, Watanabe T, Tsuruya K; Japan Specific Health Checkups (J-SHC) Study Group. Association between chronic kidney disease and new-onset dyslipidemia: the Japan Specific Health Checkups (J-SHC) study. Atherosclerosis. 2021; 332: 24-32.
  7. Nagai K, Yamagata K, Iseki K, Moriyama T, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T. Weight loss reduces the incidence of dipstick proteinuria: a cohort study from the Japanese general population. Clin Exp Nephrol. 2021; 25: 1329-1335.
  8. Kikuchi Y, Tanaka F, Nakamura M, Tanno K, Onoda T, Ohsawa M, Sakata K, Omama S, Ogasawara K, Yonekura Y, Itai K, Kuribayashi T, Ishigaki Y, Okayama A, Asahi K; Iwate-Kenco Study Group. Utility of urinary albumin excretion as an index for stratifying the residual cardiovascular risk in patients undergoing antihypertensive agents treatment. J Hypertens. 2021; 39: 2431-2438.
  9. Otaki Y, Watanabe T, Konta T, Watanabe M, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. One-year change in plasma volume and mortality in the Japanese general population: an observational cohort study. PLoS One. 2021; 16: e0254665.
  10. Araumi A, Ichikawa K, Konta T, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T. The distribution of eGFR by age in a community-based healthy population: the Japan Specific Health Checkups study (J-SHC study). Clin Exp Nephrol. 2021; 25: 1303-1310.
  11. Saito H, Tanabe H, Kudo A, Machii N, Higa M, Yamaguchi S, Maimaituxun G, Abe K, Takahashi A, Tanaka K, Asahi K, Masuzaki H, Ohira H, Kazama JJ, Shimabukuro M. High FIB4 index is an independent risk factor of diabetic kidney disease in type 2 diabetes. Sci Rep. 2021; 11: 11753.
  12. Nishimoto M, Murashima M, Yoshida H, Eriguchi M, Tasaki H, Fukata F, Kosugi T, Matsui M, Samejima KI, Iseki K, Asahi K, Yamagata K, Fujimoto S, Konta T, Narita I, Moriyama T, Kasahara M, Shibagaki Y, Kondo M, Watanabe T, Tsuruya K; Japan Specific Health Checkups (J-SHC) Study Group. Impact of self-reported walking habit on slower decline in renal function among the general population in a longitudinal study: the Japan Specific Health Checkups (J-SHC) Study. J Nephrol. 2021; 34: 1845-1853.
  13. Otaki Y, Konta T, Ichikawa K, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T. Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study. Sci Rep. 2021; 11: 8999.
  14. Hoshino J, Tsunoda R, Nagai K, Kai H, Saito C, Ito Y, Asahi K, Kondo M, Iseki K, Iseki C, Okada H, Kashihara N, Narita I, Wada T, Combe C, Pisoni RL, Robinson BM, Yamagata. Comparison of annual eGFR decline among primary kidney diseases in patients with CKD G3b-5: results from a REACH-J CKD cohort study. Clin Exp Nephrol. 2021; 25: 902-910.
  15. Nagai K, Asahi K, Iseki K, Yamagata K. Estimating the prevalence of definitive chronic kidney disease in the Japanese general population. Clin Exp Nephrol. 2021; 25:885-892.
  16. Otaki Y, Watanabe T, Konta T, Watanabe M, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Impact of chronic kidney disease on aortic disease-related mortality: a four-year community-based cohort study. Intern Med. 2021; 60: 689-697.
  17. Wakasugi M, Narita I, Iseki K, Asahi K, Yamagata K, Fujimoto S, Moriyama T, Konta T, Tsuruya K, Kasahara M, Shibagaki Y, Kondo M, Watanabe T. The effect of CKD on associations between lifestyle factors and all-cause, cancer, and cardiovascular mortality: a population-based cohort study. Intern Med. 2021; 60: 2189-2200.
  18. Saito H, Tanaka K, Iwasaki T, Oda A, Watanabe S, Kanno M, Kimura H, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease. Sci Rep. 2021; 11: 1380.
  19. Iwasaki M, Kudo A, Asahi K, Machii N, Iseki K, Satoh H, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M. Fast walking is a preventive factor against new-onset diabetes mellitus in a large cohort from a Japanese general population. Sci Rep. 2021; 11: 716.
  20. Tanaka K, Saito H, Iwasaki T, Oda A, Watanabe S, Kanno M, Kimura H, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Association between serum potassium levels and adverse outcomes in chronic kidney disease: the Fukushima CKD cohort study. Clin Exp Nephrol. 2021 Jan 7.
  21. Iseki K, Konta T, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Watanabe T. Higher cardiovascular mortality in men with persistent dipstick hematuria. Clin Exp Nephrol. 2021; 25: 150-156.
  22. Hatano Y, Yano Y, Fujimoto S, Sato Y, Iseki K, Konta T, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T. The population-attributable fraction for premature mortality due to cardiovascular disease associated with stage 1 and 2 hypertension among Japanese. Am J Hypertens. 2021; 34: 56-63.

2020年

• 1. Matsuura Y, Tanaka F, Segawa T, Tanno K, Sakata K, Ohsawa M, Omama S, Ogasawara K, Asahi K, Nakamura M. Sex differences in the influence of elevated serum uric acid levels for cardiovascular risk in the general population with normal renal function. J Iwate Med Assoc. 2020; 72:145-155.
  2. Osaki T, Satoh M, Tanaka F, Tanno K, Takahashi Y, Nasu T, Sakata K, Morino Y, Sobue K, Sasaki M: The Value of a Cystatin C-based Estimated Glomerular Filtration Rate for Cardiovascular Assessment in a General Japanese Population: Results From the Iwate Tohoku Medical Megabank Project. J Epidemiol. 2020; 30: 260-267.
  3. Hoshino J, Muenz D, Zee J, Sukul N, Speyer E, Guedes M, Lopes AA, Asahi K, van Haalen H, James G, Dhalwani N, Pecoits-Filho R, Bieber B, Robinson BM, Pisoni RL; CKDopps Investigators. Associations of Hemoglobin Levels With Health- Related Quality of Life, Physical Activity, and Clinical Outcomes in Persons With Stage 3-5 Nondialysis CKD. J Ren Nutr. 2020; 30: 404-414.
  4. Otaki Y, Watanabe T, Konta T, Watanabe M, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Impact of hyperuricemia on mortality related to aortic diseases: a 3.8-year nationwide community-based cohort study. Sci Rep. 2020; 10: 14281.
  5. Otaki Y, Watanabe T, Konta T, Watanabe M, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Impact of calculated plasma volume status on all-cause and cardiovascular mortality: 4-year nationwide community-based prospective cohort study. PLoS One. 2020; 15: e0237601.
  6. Sato Y, Fujimoto S, Iseki K, Konta T, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T. Higher baseline uric acid concentration is associated with non-attainment of optimal blood pressure. PLoS One. 2020; 15: e0236602.
  7. Iseki K, Konta T, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Iseki C, Watanabe T. Impact of Metabolic Syndrome on the Mortality Rate among Participants in a Specific Health Check and Guidance Program in Japan. Intern Med. 2020; 59: 2671-2678.
  8. Tanabe H, Saito H, Kudo A, Machii N, Hirai H, Maimaituxun G, Tanaka K, Masuzaki H, Watanabe T, Asahi K, Kazama J, Shimabukuro M. Factors Associated with Risk of Diabetic Complications in Novel Cluster-Based Diabetes Subgroups: A Japanese Retrospective Cohort Study. J Clin Med. 2020; 9: 2083.
  9. Tanabe H, Saito H, Machii N, Kudo A, Tanaka K, Asahi K, Kazama JJ, Shimabukuro M. Burden of Undiagnosed Type 2 Diabetes in Diabetic Kidney Disease: A Japanese Retrospective Cohort Study. J Clin Med. 2020; 9: 2028.
  10. Tanaka F, Komi R, Nakamura M, Tanno K, Onoda T, Ohsawa M, Sakata K, Omama S, Ogasawara K, Ishibashi Y, Yonekura Y, Itai K, Kuribayashi T, Kikuchi Y, Ishigaki Y, Okayama A, Asahi K; Iwate-Kenco Study Group. Additional prognostic value of electrocardiographic left ventricular hypertrophy in traditional cardiovascular risk assessments in chronic kidney disease. J Hypertens. 2020; 38: 1149-1157.
  11. Ikeda T, Inoue S, Konta T, Murakami M, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T. Can Daily Walking Alone Reduce Pneumonia-Related Mortality among Older People? Sci Rep. 2020; 10: 8556.
  12. Nakajima A, Tanaka K, Saito H, Iwasaki T, Oda A, Kanno M, Shimabukuro M, Asahi K, Watanabe T, Kazama JJ. Blood pressure control in chronic kidney disease according to underlying renal disease: the Fukushima CKD cohort. Clin Exp Nephrol. 2020; 24: 427-434.
  13. Konta T, Ichikawa K, Kawasaki R, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T. Association between serum uric acid levels and mortality: a nationwide community-based cohort study. Sci Rep. 2020; 10: 6066.

2019年

• 1. Nagai K, Yamagata K, Iseki K, Moriyama T, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T. Antihypertensive treatment and risk of cardiovascular mortality in patients with chronic kidney disease diagnosed based on the presence of proteinuria and renal function: A large longitudinal study in Japan. PLoS One. 2019; 14: e0225812.
  2. Nagai K, Yamagata K, Iseki K, Moriyama T, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kasahara M, Shibagaki Y, Asahi K, Watanabe T: Cause-specific mortality in the general population with transient dipstick-proteinuria. PLoS One. 2019; 14: e0223005.
  3. Nishimoto M, Tagawa M, Matsui M, Eriguchi M, Samejima KI, Iseki K, Iseki C, Asahi K, Yamagata K, Konta T, Fujimoto S, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Watanabe T, Tsuruya K: A prediction model with lifestyle in addition to previously known risk factors improves its predictive ability for cardiovascular death. Sci Rep. 2019; 9: 12953.
  4. Takahashi Y, Satoh M, Ohmomo H, Tanaka F, Osaki T, Tanno K, Nasu T, Sakata K, Morino Y, Sobue K, Sasaki M: Association between high-sensitivity cardiac troponin T and future cardiovascular incidence in a general Japanese population: results from the Tohoku medical megabank project. Biomarkers. 2019; 24: 566-573.
  5. Uchida D, Kido R, Kawarazaki H, Murasawa M, Ando A, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Konta T, Narita I, Kondo M, Kasahara M, Asahi K, Watanabe T, Shibagaki Y: Lower diastolic blood pressure was associated with higher incidence of chronic kidney disease in the general population only in those using antihypertensive medications. Kidney Blood Press Res. 2019; 44: 973-983.
  6. Nagai K, Iseki C, Iseki K, Kondo M, Asahi K, Saito C, Tsunoda R, Okubo R, Yamagata K: Higher medical costs for CKD patients with a rapid decline in eGFR: a cohort study from the Japanese general population. PLoS One. 2019; 14: e0216432.
  7. Sukul N, Speyer E, Tu C, Bieber BA, Li Y, Lopes AA, Asahi K, Mariani L, Laville M, Rayner HC, Stengel B, Robinson BM, Pisoni RL; CKDopps and CKD-REIN investigators: Pruritus and patient reported outcomes in non-dialysis CKD. Clin J Am Soc Nephrol. 2019; 14: 673-681.
  8. Sakamoto M, Edo N, Takahashi S, Okamura E, Uno K, Morita K, Ishikawa T, Asahi K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kimura K, Ohashi Y, Watanabe T, Tsukamoto K: Association between prescription and control status of dyslipidemia and hypertension among Japanese patients with diabetes. J Atheroscler Thromb. 2019; 26: 805-820.
  9. Hirai H, Asahi K, Yamaguchi S, Mori H, Satoh H, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M. New risk prediction model of coronary heart disease in participants with and without diabetes: Assessments of the Framingham risk and Suita scores in 3-year longitudinal database in a Japanese population. Sci Rep. 2019; 9: 2813.
  10. Okada H, Yasuda Y, Kashihara N, Asahi K, Tanaka K, et al. Essential points from Evidence-based Clinical Practice Guidelines for Chronic Kidney Disease 2018. Clin Exp Nephrol. 2019; 23: 1-15.

2018年

• 1. Otaki Y, Watanabe T, Konta T, Watanabe M, Fujimoto S, Sato Y, Asahi K, Yamagata K, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Watanabe T. Effect of Hypertension on Aortic Artery Disease-Related Mortality　- 3.8-Year Nationwide Community-Based Prospective Cohort Study. Circ J. 2018; 82: 2776-2782.
  2. Ogata E, Asahi K, Yamaguchi S, Iseki K, Sato H, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M. Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population. Sci Rep. 2018 Sep 17; 8:13927.
  3. Tanaka K, Tanaka F, Onoda T, Tanno K, Ohsawa M, Sakata K, Omama S, Ogasawara K, Ishibashi Y, Itai K, Kuribayashi T, Okayama A, Nakamura M; Iwate-Kenco Study Group. Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population. Am J Hypertens. 2018; 31: 895-901.
  4. Komi R, Tanaka F, Omama S, Ishibashi Y, Tanno K, Onoda T, Ohsawa M, Tanaka K, Okayama A, Nakamura M; Iwate-Kenco Study Group. Burden of high blood pressure as a contributing factor to stroke in the Japanese community-based diabetic population. Hypertens Res. 2018; 41: 531-538.